Ameloblastic carcinoma is a rare form of odontogenic tumor, one that develops in the jawbones from the epithelial cells that generate the tooth enamel. Mandible / maxilla – Malignant tumors: ameloblastic carcinoma. Ameloblastic carcinoma is a rare odontogenic malignancy that combines the histological features of ameloblastoma with cytological atypia.

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Ameloblastic Carcinoma

Histopathological picture showing bizarre mitosis, altered nuclear chromatin ratio, hyperchromatisim, mild pleomorphism, and central stellate reticulum confirming ameloblastic carcinoma. Published online Mar Carxinoma Head Neck Surg. Report of a new case, literature review, and comparison to ameloblastoma.

Malignant epithelial odontogenic tumors. Screening for metastatic disease should be done, especially in recurrent cases of typical ameloblastoma, malignant ameloblastoma, and ameloblastic carcinoma [ 19 ]. Chemotherapy has not been indicated as a primary treatment Involvement of the maxilla by ameloblastic carcinoma seems to be less frequent than that of the mandible [ 910 ].

Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature

Aemloblastic, Jensen et al 26 reported the use of carbon ion therapy for recurrent ameloblastic carcinoma over four weeks, which showed no recurrence following three months.

The maxillomandibular ratio of ameloblastoma is 5: Ameloblastic carcinoma of the jaws: Discussion The ameloblastoma is an odontogenic tumour of the ameloblaztic, arising from dental embryonic remnants possibly from the epithelial lining of an odontogenic cyst; dental lamina or enamel organ; stratified squamous epithelium of the oral cavity; or displaced epithelial remnants [ 8 ]. Report of an aggressive case with multiple bony metastases.


Diagnosis A diagnosis of ameloblastic carcinoma is made based upon a thorough clinical evaluation, a detailed patient history, and microscopic examination of the tumor. Naik and Kale 17 also reported that surgical stimulation and incomplete resection may induce the degeneration of early lesions, and explain the higher recurrence rate following partial resection, which was identified in patients with secondary ameloblastic carcinoma compared with primary.

ACs are extremely rare malignant odontogenic epithelial neoplasm and may arise de novo or from a pre-existing odontogenic lesion [ 914 ]. Secondary dedifferentiated carcinoma of the mandible: Naik V and Kale AD: The evolution of ameloblastoma to ameloblastic carcinoma is controversial The ameloblastic carcinomas were classified as primary or secondary by a reviewing pathologist using the WHO criteria 8.

Resources Ameloblastic Carcinoma Resources. Postoperative panoramic image demonstrating bone loss between the bilateral mandibular ramus and the reconstruction plate was placed in the defect area to aid with repair.

Low-grade spindle-cell ameloblastic carcinoma: Home About Us Advertise Amazon. Ameloblastic carcinoma of the maxilla: Carcinoma refers to a malignancy that arises from epithelium. Overlying mucosa was normal in colour, mildly tender and firm to hard in consistency Fig. Mandibular ameloblastic carcinoma in a young patient. A Rationale for Diagnosis and Treatment. Author ameloblsstic Article notes Copyright and License information Disclaimer.

Wide surgical excision provides the best chance of controlling the tumor. Majority arise de novo Less commonly arise from pre-existing ameloblastoma, a,eloblastic are considered secondary or dedifferentiated lesions. CT scan showed, lesion involving right ramus and coronoid process of mandible measuring 2.


In our case series, least follow-up until date is 22 months and maximum follow-up being 39 months. Ameloblastic carcinoma is a rare odontogenic tumor exhibiting not only features of ameloblastoma, but also features of carcinoma. Controlled studies with larger groups of patients are required to increase the accuracy of results.

Ameloblastic carcinoma ex ameloblastoma of the mandible: Much confusion exists in the medical literature regarding the classification of malignant odontogenic tumors. Granular cell ameloblastoma with metastasis to the cervical vertebrae. Postoperative panoramic view of one patient showing a large area of bone loss in the mandible.

J Maxillofac Oral Surg ;9: Ameloblastic carcinoma spindle cagcinoma variant.

Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature

The patient realized the swelling grew in size even after the extraction of teeth. One study has shown that malignant transformation requires a relatively long duration, and multistage carcinogenesis is a reasonable suggestion as to the underlying mechanism of malignant transformation J Can D Assoc.

Retrieved articles were extensively reviewed for epidemiology, etiology, diagnosis, treatment options, and prognosis of ameloblastic carcinoma.

Operated site after the resection of tumour hemimandibulectomy done followed ameloblstic placement of 2. None of our patients were sent for radiotherapy or chemotherapy.