ABSTRACT. The present study aimed to evaluate the in vitro antimicrobial activity of pharmacologically important Adhatoda vasica plant extracts. Plant Adhatoda vasica L. Nees (Acanthaceae) commonly known as Malabar nut is an evergreen two – three m tall shrub, sometime used as. Adhatoda vasica (L.) (Acanthaceae) is used in the indigenous system of medicine in India. The alkaloid Vasicine was isolated from ethanolic extract of the .

Author: Brajind Kirr
Country: Bahrain
Language: English (Spanish)
Genre: Science
Published (Last): 20 May 2014
Pages: 174
PDF File Size: 17.46 Mb
ePub File Size: 1.97 Mb
ISBN: 826-1-33052-149-6
Downloads: 64440
Price: Free* [*Free Regsitration Required]
Uploader: Zululkree

Ignacimuthu and Shanmugam [ 15 ] have reported the antitubercular activity of Vasicine acetate isolated from A.

Antibacterial activity of adhatoda vasica leaf extract

Antimycobacterial activity of two natural alkaloids, vasicine acetate and 2-acetyl benzylamine, isolated from Indian shrub Adhatoda vasica Ness. The fraction was further purified and the compound Vasicine was isolated.

Vasicine acetate could be checked further in drug discovery programme. The plant is used in the indigenous system of medicine in India and is a antimicorbial expectorant in both Ayurvedic and Unani Systems of Medicine [ 45 ]. The spot turned orange red on spraying with Dragendorff’s reagent. Nature acts as a prominent reservoir for new and novel therapeutics. Cytotoxicity of each sample was expressed as IC 50 value.

A voucher specimen No. Vasicine acetate could be probed further in drug discovery programme. Antimicrobial and antimycobacterial activities of methyl caffeate isolated from Solanum torvum Swartz. The chemicals are given in delta scale acttivity TMS as an internal standard. Support Center Support Center.


Glossary of Indian Medicinal Plants. Cytotoxic A and antimicrobial effects of Methylobacterium sp. Vasicine acetate was obtained by acetylation of Vasicine.

Materials and Methods 2. Natural products still remain the most important source for discovery of new and potential drug molecules. Minimum Inhibitory Concentration MIC Minimum inhibitory concentration studies of the compounds were performed according to the standard reference methods for bacteria [ 17 ] and filamentous fungi [ 18 ].

Indian Journal of Medical Research. Two mobile phases A and B were used at flow rate of 1. Instruments All melting point values are uncorrected and taken by open capillary method on a antmiicrobial block Instrument.

Preliminary phytochemical and antibacterial screening of crude extract of the leaf of Adhatoda vasica.

Essential oils of the leaves of A. Please review our privacy policy. Antitussive effect of Adhatoda vasica extract on mechanical or chemical stimulation-induced coughing in animals. A human adenocarcinoma cancer cell line was obtained from National Institute of Cell Sciences, Pune.

Clinical and Laboratory Standards Institute; Vasicine acetate showed minimum inhibitory concentration values against bacteria; they were M. Mobile phase A consisted of water with 0. Vasicine showed antimicrobial activity against S. Vasicine acetate showed moderate antibacterial activity compared to Vasicine.


Antibacterial Activity of Leaf Extracts of Adhatoda vasica – MAHE Digital Repository

Potent uterine activity of alkaloid vasicine. UV-Visible spectra were taken in methanol on Thermo Fisher instrument. Streptomycin was used as positive control for bacteria and Ketoconazole as positive control for fungi.

The plant is reported to show abortifacient [ 7 ], antimicrobial [ 89 ], and antitussive activities [ 10 ]. All melting point values are uncorrected and taken by open capillary method on a heating block Instrument.

Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

It was studied for antimicrobial, antioxidant, and anticancer activities. Introduction Natural products still remain the most important source for discovery of new and potential drug molecules. Journal of Natural Product and Plant Resources. Journal List Biomed Res Int v. Minimum inhibitory concentration of Vasicine acetate against tested bacteria and fungi.

International Journal of Cancer. Cytotoxic effect of Vasicine acetate against A lung adenocarcinoma cancer cell line. Antibacterial and antifungal activities were carried out using disc diffusion method [ 16 ].

Vasicine acetate showed antimycobacterial activity [ 15 ]. Further elution of the column with chloroform: Abstract Adhatoda vasica L.