extract of Glycyrrhiza glabra Linn. in aspirin induced ulcer in rats. . The aim of the study was to determine anti ulcer activity of stem bark of. Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total Keywords: Anti-ulcer, Cold-restraint, Glycyrrhiza glabra, GutGardTM. The present research has been carried out to investigate antiulcer activity of ethanolic extract of Cynodon dactylon, Ocimum sanctum, Glycyrrhiza glabra, Ficus.

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This model, cold restraint stress-induced gastric ulcers, has been used due to data reproducibility and similarity with human gastric ulcers to evaluate the effect of drugs on gastric secretion, stress and antiulcee motility. Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. The experimental data were tested for statistical significance by means of analysis of variance with one-way classification. Find articles by Ehsan Anassori.

The stomachs were gently rinsed with water to remove the antiulced contents and blood clots, for subsequent examination.

Effects of naringenin and quercetin on experimental chronic gastric ulcer in rat studies on the histological findings. Ulcer index and preventive index of each of the groups was calculated using standard methods as described above.

Animals The study was conducted on Swiss mice of either sex, weighing 25—30 g. The gastric mucosa was examined for lesions with a binocular stereomicroscope Nikon SMZ A depletion of stomach wall mucus after oral ethanol administration has also been reported This article has been cited by antiulcrr articles in PMC.

A possible anti-inflammatory and anti-ulcer drug.

Anti Ulcer Activity Of Aloevera And Glycyrrhiza Glabra In Swiss Albino Rats |

HEGG reduced the ulcer index in hypothermic stress induced gastric ulcers in mice and the antiulcer effect was comparable to that of cimetidine. Thereby it was reported, G. Anti-Helicobacter pylori activity and Structure-Activity Relationship study of 2-Alkylthio nitroaryl -1,3,4-thiadiazole Derivatives. Please review our privacy policy. Anti-ulcer effects of antioxidants, quercetin, alpha-tocopherol, nifedipine and tetracycline in rats. Ethanol-induced gastric ulcer According to the method of Cerqueira et al.


Nassiri M, Hosseinzadeh H. Open in a separate window. The preventive effect was calculated by the method of Basile et al. Extraction of Glycyrrhizic Acid and Glabridin from Licorice.

Modern trends in toxicology. The HEGG-induced gastroprotection in higher and lower doses were more effective. Experimental Extract preparation The plant G. Therefore, search for natural active and better alternative for the treatment of peptic ulcer with fewer side effects is an emergency need.

The experiment was performed by the method of Sairam et al. Prior to the biological experimentation on animals, the protocols were approved by the Institutional Animals Ethical Committee of the Faculty of Veterinary Medicine, Urmia University. Hence, it is assumed that flavonoids may contribute at least in part to the antiulcer effect of the plants. Although the etiology of gastric ulcers is still debated, it is accepted that ulcers are caused due to imbalances in mucosal aggressive and self-protective factors.

Cimetidine, omeprazole, and indomethacin were purchased from Sigma Sigma Chemical Co. In this study, the antiulcer effect of Hydroalcoholic extract of G.

A voucher specimen number was kept in the herbarium. Oral treatment with indomethacin developed considerable ulcers in the glandular portion of stomach.

Gastric contents and blood clots were removed then the stomach rinsed in formaldehyde and fixed between two glass plates. Abstract Glycyrrhiza glabra L. The anti-gastroulcerative activity of beta-sitosterol-beta-d-glucoside and its aglycone in rats.

Anti-ulcer activity of aqueous and ethanolic extracts of Glycyrrhiza glabra L. in rats.

Ulcer index and preventive index was calculated following the method as described above. Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models. Indomethacin induced gastric ulcers is used to study the role of prostaglandins on gastric cytoprotection.


It seems that by raising the local concentration of prostaglandins that promote mucous secretion and cell proliferation in the stomach, leading to healing of ulcers in experimental studies Aqueous extracts and polysaccharides from Liquorice roots Glycyrrhiza glabra L. Home Publications Conferences Register Contact.

HEGG has antiulcer properties and significantly reduced the damage of gastric mucosa induced by indomethacin, suggesting that its gastroprotective effect involves the increase in the prostaglandin synthesis.

Peptic antuulcer is a major gastro-intestinal disorder caused by an imbalance between offensive gastric acid, pepsinogen secretion and defensive mucous secretion, gastric mucosal integrity factors. Publication Policies and Ethics.

The following scores were used: The possibility of HEGG exerting a cytoprotective effect is indicated because it successfully prevents the formation of gastric lesions in the indomethacin and ethanol induced ulcer models.

Several studies have indicated that Glycyrrhiza glabra extract or its derivatives, mainly glycyrrhizin, bear expectorant, diuretic, laxative, sedative, antipyretic, antimicrobial and anxiolytic, antiviral, anti-inflammatory and antioxidant activities 4. The hydroalcoholic extract of Glycyrrhiza glabra L.

Anti-ulcer properties of saponins have been reported Antiulcer activity of Sapindus saponaria L. Roles of endogenous prostaglandins and cyclooxygenase isozymes in mucosal defense of inflamed rat stomach.

M College of Pharmacy. Review of Pharmacological Effects of Glycyrrhiza sp. Open Access Open Access. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P